2024TRAINRestrictive transfusionIn 820 patients with acute brain injury, a liberal transfusion threshold (Hb 9 g/dL) reduced unfavourable neurologic outcome at 180 days versus restrictive (Hb 7 g/dL).
2023MINTRestrictive transfusionIn 3,504 patients with acute myocardial infarction and Hb <10 g/dL, a restrictive transfusion strategy (Hb <8) did not change 30-day death or recurrent MI versus a liberal strategy (Hb <10), with a trend toward harm.
2020HALT-ITTranexamic acidIn 12,009 patients with acute GI bleeding, tranexamic acid did not reduce death from bleeding versus placebo, and increased venous thromboembolism.
2019CRASH-3Tranexamic acidIn 12,737 patients with traumatic brain injury, tranexamic acid did not reduce head-injury death overall versus placebo, with benefit in mild–moderate TBI.
2015PROPPRTrauma resuscitationIn 680 patients with severe trauma haemorrhage, a 1:1:1 plasma:platelet:RBC ratio did not change 24-hour or 30-day mortality versus 1:1:2, but reduced death from exsanguination at 24 hours.
2014TRISSRestrictive transfusionIn 998 patients with septic shock, transfusion threshold Hb 7 g/dL did not change 90-day mortality versus Hb 9 g/dL.
2010CRASH-2Tranexamic acidIn 20,211 trauma patients with significant haemorrhage, tranexamic acid within 3 hours reduced all-cause death versus placebo.
1999TRICCRestrictive transfusionIn 838 euvolaemic ICU patients, a restrictive transfusion threshold of Hb 7 g/dL did not change 30-day mortality versus a liberal threshold of Hb 10 g/dL.