TrialsgrambetaRCTs are beautiful

Sedation, analgesia & delirium

5 trials
  • 2019SPICE-IIIDexmedetomidineIn 4,000 mechanically ventilated ICU patients, early dexmedetomidine did not change 90-day mortality versus usual sedation, with more bradycardia and hypotension.
  • 2018MIND-USADeliriumIn 566 ICU patients with delirium, haloperidol or ziprasidone did not change delirium duration versus placebo.
  • 2016DahLIADeliriumIn 74 patients with agitated delirium preventing extubation, dexmedetomidine accelerated ventilator-free hours versus placebo.
  • 2009SEDCOMDexmedetomidineIn 375 mechanically ventilated ICU patients, dexmedetomidine reduced delirium compared with midazolam.
  • 2008ABCSpontaneous awakeningIn 336 mechanically ventilated ICU patients, a daily spontaneous-awakening + breathing trial increased ventilator-free days versus breathing trials alone, and reduced 1-year mortality.