Cardiogenic shock & MCS
6 trials- 2023ECMO-CSMechanical supportIn 117 patients with rapidly deteriorating cardiogenic shock, immediate VA-ECMO did not change 30-day composite of death or escalation versus early-conservative strategy.
- 2023ECLS-SHOCKMechanical supportIn 420 patients with acute MI complicated by cardiogenic shock, VA-ECMO did not reduce 30-day mortality versus standard care, with more bleeding and vascular complications.
- 2021DOREMIInotropesIn 192 patients with cardiogenic shock, milrinone produced similar rates of death and major complications compared with dobutamine.
- 2017CULPRIT-SHOCKRevascularisationIn 706 patients with multivessel disease and cardiogenic shock, culprit-only PCI with staged completion reduced 30-day death or RRT compared with immediate multivessel PCI.
- 2012IABP-SHOCK IIMechanical supportIn 600 patients with MI-related cardiogenic shock undergoing revascularisation, intra-aortic balloon counterpulsation did not reduce 30-day mortality versus no IABP.
- 1999SHOCKRevascularisationIn 302 patients with myocardial-infarction cardiogenic shock, early revascularisation did not reduce 30-day mortality versus initial medical stabilisation, but improved 6-month survival.