DOREMI
Milrinone versus Dobutamine in Cardiogenic Shock
Patient / Population Intervention / Exposure Comparison Outcome
In 192 patients with cardiogenic shock, milrinone produced similar rates of death and major complications compared with dobutamine.
N
192
Design
Double-blind RCT
Endpoint
Composite of death, resuscitated arrest, mechanical support and other events
Relevance
3
ResultNo significant difference between the two inotropes.
Mathew R, et al. N Engl J Med. 2021;385(6):516-525. 10.1056/NEJMoa2026845
Discussion & critique
No winning inotrope in cardiogenic shock — the choice is by patient characteristics and side-effect profile, not outcomes.