TrialsgrambetaRCTs are beautiful

Critical care cardiology

6 trials
  • 2021TTM2Temperature managementIn 1,861 unconscious adults after OHCA, hypothermia at 33 °C did not reduce all-cause mortality at 6 months compared with targeted normothermia (≤ 37.5 °C).
  • 2021DOREMIInotropesIn 192 patients with cardiogenic shock, milrinone produced similar rates of death and major complications compared with dobutamine.
  • 2019HYPERIONTemperature managementIn 581 patients resuscitated from cardiac arrest with a non-shockable rhythm, targeted hypothermia at 33 °C improved favourable neurological outcome compared with targeted normothermia.
  • 2017CULPRIT-SHOCKRevascularisationIn 706 patients with multivessel disease and cardiogenic shock, culprit-only PCI with staged completion reduced 30-day death or RRT compared with immediate multivessel PCI.
  • 2013TTMTemperature managementIn 939 unconscious survivors of out-of-hospital cardiac arrest, targeted temperature of 33 °C did not improve survival or neurological outcome compared with 36 °C.
  • 2010SOAP IIVasopressorsIn 1,679 patients with shock, noradrenaline produced similar mortality but fewer arrhythmias compared with dopamine.