2022PLUSBalanced crystalloidsIn 5,037 ICU patients, Plasma-Lyte 148 did not change 90-day mortality versus saline.
2021BaSICSBalanced crystalloidsIn 11,052 ICU patients, Plasma-Lyte did not reduce 90-day mortality compared with saline, with possible harm in traumatic brain injury.
2018SMARTBalanced crystalloidsIn 15,802 ICU patients, balanced crystalloids reduced the composite of major adverse kidney events at 30 days versus saline.
2012CHESTHydroxyethyl starchIn 7,000 ICU patients, 6% HES 130/0.4 did not reduce 90-day mortality versus saline, but increased renal-replacement therapy.
20126SHydroxyethyl starchIn 804 patients with severe sepsis, 6% HES 130/0.42 increased 90-day death or dialysis versus Ringer's acetate.
2004SAFEAlbumin vs crystalloidIn 6,997 ICU patients requiring fluid resuscitation, 4% albumin did not change 28-day mortality versus 0.9% saline, with harm in the traumatic brain injury subgroup.