2021AKIKI 2RRT timingIn 278 patients with AKI and no urgent indication, a more-delayed renal-replacement strategy did not improve survival and trended toward harm compared with a delayed strategy.
2020STARRT-AKIRRT timingIn 3,019 critically ill patients with acute kidney injury, accelerated renal-replacement therapy did not reduce mortality and increased dialysis dependence compared with a standard strategy.
2018PRESERVEContrast-associated AKIIn 5,177 high-risk patients undergoing angiography, intravenous sodium bicarbonate or acetylcysteine did not reduce contrast-associated kidney outcomes compared with control.
2017AMACINGContrast-associated AKIIn 660 patients with CKD undergoing contrast procedures, withholding prophylactic intravenous hydration was non-inferior for preventing contrast-associated AKI compared with hydration.
2017PrevAKICare bundlesIn 276 high-risk cardiac-surgery patients identified by biomarkers, a KDIGO care bundle reduced acute kidney injury compared with standard care.
2016ELAINRRT timingIn 231 critically ill patients with acute kidney injury, early renal-replacement therapy reduced 90-day mortality compared with delayed initiation.
2016AKIKIRRT timingIn 620 critically ill patients with stage 3 AKI, an early renal-replacement strategy did not improve survival compared with a delayed strategy.
2009RENALRRT doseIn 1,508 critically ill patients with acute kidney injury, higher-intensity continuous renal-replacement therapy did not reduce mortality compared with lower-intensity therapy.
2008ATNRRT doseIn 1,124 critically ill patients with acute kidney injury, intensive renal-replacement therapy did not reduce mortality compared with less-intensive therapy.