RENAL
Randomised Evaluation of Normal versus Augmented Level of RRT
Patient / Population Intervention / Exposure Comparison Outcome
In 1,508 critically ill patients with acute kidney injury, higher-intensity continuous renal-replacement therapy did not reduce mortality compared with lower-intensity therapy.
N
1,508
Design
Multicentre RCT
Endpoint
90-day all-cause mortality
Relevance
2
Result44.7% vs 44.7%; OR 1.00 (95% CI 0.81–1.23; p=0.99).
RENAL Replacement Therapy Study Investigators. N Engl J Med. 2009;361(17):1627-1638. 10.1056/NEJMoa0902413
Discussion & critique
With ATN, set the recommended CRRT dose at 20–25 mL/kg/h.