AKIKI 2
Artificial Kidney Initiation in Kidney Injury 2
Patient / Population Intervention / Exposure Comparison Outcome
In 278 patients with AKI and no urgent indication, a more-delayed renal-replacement strategy did not improve survival and trended toward harm compared with a delayed strategy.
N
278
Design
Multicentre RCT
Endpoint
Days alive and free of RRT to day 28 (60-day mortality secondary)
Relevance
3
ResultNo mortality benefit; a trend to higher mortality with the most-delayed strategy (HR 1.65; 95% CI 1.09–2.50).
Gaudry S, et al. Lancet. 2021;397(10281):1293-1300. 10.1016/S0140-6736(21)00350-0
Discussion & critique
Defined the lower bound of safe delay: waiting too long is harmful.