2023INCEPTIONECPRIn 160 patients with refractory OHCA, ECPR did not improve 30-day survival with favourable neurology versus conventional CPR.
2022BOX (BP)Haemodynamic targetsIn 789 comatose survivors of OHCA, a higher MAP target (77 mm Hg) did not change the composite of death or severe disability versus a lower target (63 mm Hg).
2022BOX (O₂)Oxygen targetsIn 789 comatose survivors of OHCA, restrictive oxygenation (PaO₂ 68–75 mm Hg) did not change the composite of death or severe disability compared with liberal (98–105 mm Hg).
2022DOSE-VFDefibrillationIn 405 patients with refractory ventricular fibrillation, double sequential external defibrillation improved survival to hospital discharge versus standard defibrillation.
2021TTM2Temperature managementIn 1,861 unconscious adults after OHCA, hypothermia at 33 °C did not reduce all-cause mortality at 6 months compared with targeted normothermia (≤ 37.5 °C).
2020ARRESTECPRIn 30 patients with refractory out-of-hospital VF arrest, ECPR plus expedited coronary angiography improved survival to hospital discharge versus standard ACLS.
2019HYPERIONTemperature managementIn 581 patients resuscitated from cardiac arrest with a non-shockable rhythm, targeted hypothermia at 33 °C improved favourable neurological outcome compared with targeted normothermia.
2018PARAMEDIC2AdrenalineIn 8,014 adults with OHCA, 1 mg intravenous adrenaline increased 30-day survival versus placebo, without improving favourable neurologic survival.
2013TTMTemperature managementIn 939 unconscious survivors of out-of-hospital cardiac arrest, targeted temperature of 33 °C did not improve survival or neurological outcome compared with 36 °C.
2002HACATemperature managementIn 275 comatose survivors of out-of-hospital VF arrest, therapeutic hypothermia 32–34 °C for 24 hours improved favourable neurologic outcome at 6 months versus standard normothermia.
2002Bernard 2002Temperature managementIn 77 comatose survivors of out-of-hospital VF arrest, hypothermia to 33 °C improved good neurologic outcome compared with normothermia.