DOSE-VF
Double Sequential External Defibrillation
Patient / Population Intervention / Exposure Comparison Outcome
In 405 patients with refractory ventricular fibrillation, double sequential external defibrillation improved survival to hospital discharge versus standard defibrillation.
N
405
Design
Cluster-randomised crossover trial, Canada
Endpoint
Survival to hospital discharge
Relevance
2
Result30.4% vs 13.3% (RR 2.21; 95% CI 1.33–3.67). Vector change non-significant.
Cheskes S, et al. N Engl J Med. 2022;387(21):1947-1956. 10.1056/NEJMoa2207304
Discussion & critique
Cluster-randomised so not perfectly individual-level, but the effect size is large enough to motivate practice change in refractory VF.