2022DOSE-VFDefibrillationIn 405 patients with refractory ventricular fibrillation, double sequential external defibrillation improved survival to hospital discharge versus standard defibrillation.
2021VAM-IHCAIn 501 adults with in-hospital cardiac arrest, vasopressin plus methylprednisolone increased return of spontaneous circulation compared with placebo.
2021COCAIn 391 adults with out-of-hospital cardiac arrest receiving epinephrine, calcium chloride did not improve sustained return of spontaneous circulation compared with saline placebo.
2018PARAMEDIC2AdrenalineIn 8,014 adults with OHCA, 1 mg intravenous adrenaline increased 30-day survival versus placebo, without improving favourable neurologic survival.
2016ALPSAntiarrhythmicsIn 3,026 adults with OHCA and shock-refractory VF/pVT, amiodarone or lidocaine did not improve survival to hospital discharge versus placebo.
2015PARAMEDIC (LUCAS-2)Mechanical CPRIn 4,471 out-of-hospital cardiac arrests, LUCAS-2 mechanical chest compression did not improve 30-day survival versus manual CPR, and worsened functional outcome at 3 months.
2015ROC CCCIn 23,711 adults with out-of-hospital cardiac arrest, continuous chest compressions by EMS did not improve survival to discharge versus interrupted compressions.
2015Mobile-Phone Dispatch of Laypersons for CPR in Out-of-HospitIn667 out-of-hospital cardiac arrests in Stockholm,mobile-phone dispatch of nearby CPR-trained volunteersincreasedbystander-initiated CPR before EMS arrivalcompared withno volunteer dispatch.
2013PRESENCEIn 570 relatives of adults receiving prehospital CPR, routinely offering family presence reduced PTSD symptoms at 90 days compared with standard practice.
2013VSEIn 268 adults with in-hospital cardiac arrest, vasopressin plus steroids added to epinephrine improved neurologically intact survival to discharge versus epinephrine alone.