Status epilepticus & neuro emergency
4 trials- 2019ESETTSecond-line anticonvulsantsIn 478 patients with benzodiazepine-refractory status epilepticus, levetiracetam was equivalent on seizure cessation and alertness at 60 min to fosphenytoin or valproate.
- 2019EcLiPSEIn 286 children with benzodiazepine-refractory convulsive status epilepticus, levetiracetam did not shorten time to seizure cessation versus phenytoin.
- 2019ConSEPTIn 233 children with benzodiazepine-refractory convulsive status epilepticus, levetiracetam did not achieve seizure cessation more often than phenytoin.
- 2012RAMPARTBenzodiazepinesIn 893 patients with prehospital status epilepticus, intramuscular midazolam 10 mg was non-inferior and superior on seizure cessation by ED arrival versus intravenous lorazepam 4 mg.