2023SELECT2Large-core thrombectomyIn 352 patients with large ischaemic core (ASPECTS 3–5 or core ≥ 50 mL), endovascular thrombectomy improved the 90-day mRS distribution versus medical management.
2023ANGEL-ASPECTLarge-core thrombectomyIn 456 Chinese patients with LVO and large ischaemic core, endovascular therapy improved the 90-day mRS distribution versus medical management.
2018DAWNLate-window thrombectomyIn 206 patients with LVO stroke 6–24 h from last known well, thrombectomy + standard care improved functional independence at 90 days versus standard care.
2018DEFUSE 3Late-window thrombectomyIn 182 patients with anterior-circulation LVO 6–16 h, small core and perfusion mismatch, thrombectomy improved functional outcome at 90 days versus medical management.
2018WAKE-UPMRI-guided lysisIn 503 patients with ischaemic stroke of unknown onset and DWI–FLAIR mismatch, alteplase improved mRS 0–1 at 90 days versus placebo.
2018EXTEND-IA TNKTenecteplaseIn 202 patients with LVO before thrombectomy within 4.5 h, tenecteplase 0.25 mg/kg improved pre-thrombectomy reperfusion versus alteplase 0.9 mg/kg.
2015MR CLEANThrombectomyIn 500 patients with proximal anterior-circulation occlusion within 6 h, intra-arterial thrombectomy + standard care improved the 90-day mRS distribution versus standard care alone.
2008ECASS IIIIV thrombolysisIn 821 patients with acute ischaemic stroke 3–4.5 h from onset, alteplase improved mRS 0–1 at 90 days versus placebo.
1995NINDS rt-PAIV thrombolysisIn 624 patients with acute ischaemic stroke within 3 h, intravenous alteplase 0.9 mg/kg improved functional outcome at 3 months versus placebo.