TTM
Targeted Temperature Management
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 939 unconscious survivors of out-of-hospital cardiac arrest, targeted temperature of 33 °C did not improve survival or neurological outcome compared with 36 °C.
N
939
Design
Open-label, blinded endpoint RCT
Endpunkt
All-cause mortality at end of trial
Relevanz
2
Ergebnis50 % vs 48 % mortality (HR 1.06, ns). Neuro outcomes similar.
Nielsen N, et al. N Engl J Med. 2013;369(23):2197-2206. 10.1056/NEJMoa1310519
Diskussion & Kritik
Challenged the HACA / Bernard hypothermia paradigm. Both arms strictly avoided fever — argued the benefit may be from fever-avoidance, not hypothermia per se.