2023 ESC Guidelines for the management of acute coronary syndromes
The 2023 ESC Guidelines unify STEMI and NSTE-ACS into a single acute coronary syndrome pathway, covering reperfusion, antithrombotic therapy, revascularisation and secondary prevention. This page maps the landmark trials from our register that the guideline cites — grouped by theme.
This guideline cites 18 of the 199 landmark trials in our Cardiology register.
Antithrombotic & antiplatelet therapy7
- 2019ISAR-REACT 5Cardiology · Coronary · AntiplateletsTicagrelor or Prasugrel in Patients with Acute Coronary Syndromes
- 2019AUGUSTUSCardiology · Thrombosis · AF + PCIAntithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation
- 2013WOESTCardiology · Thrombosis · AF + PCIWhat is the Optimal antiplatelet and anticoagulant therapy in patients with OAC and coronary StenTing
- 2009PLATOCardiology · Coronary · AntiplateletsPlatelet Inhibition and Patient Outcomes
- 2007TRITON-TIMI 38Cardiology · Coronary · AntiplateletsTrial to Assess Improvement in Therapeutic Outcomes
- 2005COMMITCardiology · Coronary · clopidogrelClOpidogrel and Metoprolol in Myocardial Infarction Trial (Second Chinese Cardiac Study, CCS-2)
- 2001CURECardiology · Coronary · AntiplateletsClopidogrel in Unstable Angina to Prevent Recurrent Events
Reperfusion & revascularisation3
- 2019COMPLETECardiology · Coronary · RevascularisationComplete vs Culprit-Only Revascularisation Strategies
- 2017CULPRIT-SHOCKICU · CS / MCS · RevascularisationCulprit-Lesion-Only versus Multivessel PCI in Cardiogenic Shock
- 1988ISIS-2Cardiology · Coronary · ReperfusionSecond International Study of Infarct Survival
Lipid-lowering & secondary prevention6
- 2019REDUCE-ITCardiology · Lipids · TriglyceridesReduction of Cardiovascular Events with Icosapent Ethyl
- 2018ODYSSEY OUTCOMESCardiology · Lipids · PCSK9 inhibitorEvaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab
- 2017FOURIERCardiology · Lipids · PCSK9iFurther Cardiovascular Outcomes Research with PCSK9 Inhibition
- 2017COMPASSCardiology · Thrombosis · Chronic atherosclerosisCardiovascular Outcomes for People Using Anticoagulation Strategies
- 2015IMPROVE-ITCardiology · Lipids · Non-statin LDLImproved Reduction of Outcomes: Vytorin Efficacy International Trial
- 2004PROVE-ITCardiology · Lipids · StatinsPravastatin or Atorvastatin Evaluation and Infection Therapy — Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22)