TTM2
Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest
Paciente / Población Intervención / Exposición Comparación Desenlace
In 1,861 unconscious adults after OHCA, hypothermia at 33 °C did not reduce all-cause mortality at 6 months compared with targeted normothermia (≤ 37.5 °C).
N
1861
Diseño
Open-label, blinded endpoint RCT
Desenlace
6-month all-cause mortality
Relevancia
1
Resultado50 % vs 48 % (RR 1.04, ns).
Dankiewicz J, et al. N Engl J Med. 2021;384(24):2283-2294. 10.1056/NEJMoa2100591
Discusión y crítica
Definitive: targeted normothermia (fever avoidance) is now the standard. Subgroup of in-hospital arrest not studied; shockable & non-shockable rhythms both included.