2023INTERACT-3ICH care bundleIn 7,036 patients with acute ICH across 121 hospitals, a bundle of BP, glucose, temperature and anticoagulation reversal improved functional outcome at 6 months versus usual care.
2022SETPOINT2TracheostomyIn 382 ventilated patients with severe stroke, early tracheostomy (≤4 days) did not improve 6-month functional outcome versus standard timing (7–10 days).
2016RESCUEicpCraniectomyIn 408 patients with TBI and refractory raised ICP, late-tier craniectomy reduced 6-month mortality compared with medical management, at the cost of more vegetative state and severe disability.
2016ATACH-2ICH blood pressureIn 1,000 patients with acute ICH, aggressive SBP 110–139 mm Hg did not change 90-day death or disability versus standard 140–179 mm Hg, with more renal adverse events.
2013INTERACT-2ICH blood pressureIn 2,839 patients with acute intracerebral haemorrhage, intensive blood-pressure lowering (SBP <140) did not reduce 90-day death or major disability versus standard (<180), but improved ordinal mRS.
2011DECRACraniectomyIn 155 patients with severe diffuse TBI and refractory raised ICP, early bifrontal craniectomy worsened 6-month functional outcome versus standard care.