HIV
4 trials- 2021HPTN 083Long-acting PrEPIn 4,566 cisgender MSM and transgender women at high risk of HIV, long-acting injectable cabotegravir every 8 weeks reduced HIV acquisition compared with daily oral TDF/FTC.
- 2019PARTNER / PARTNER2U=UIn ≥1,000 serodifferent couples, HIV transmission during condomless sex when the HIV+ partner had viral load <200 copies/mL produced zero phylogenetically linked transmissions across ≥76,000 condomless sex acts.
- 2015STARTUniversal early ARTIn 4,684 ART-naïve adults with CD4 >500/µL, immediate antiretroviral therapy reduced serious AIDS and non-AIDS events compared with deferred ART.
- 2011HPTN 052Treatment as preventionIn 1,763 HIV-serodiscordant couples, early antiretroviral therapy of the HIV-positive partner reduced linked HIV transmission compared with delayed ART.