PARTNER / PARTNER2
Prospective Studies of Risk of HIV Transmission with Suppressed Viral Load
Patient / Population Intervention / Exposure Comparison Outcome
In ≥1,000 serodifferent couples, HIV transmission during condomless sex when the HIV+ partner had viral load <200 copies/mL produced zero phylogenetically linked transmissions across ≥76,000 condomless sex acts.
N
972
Design
Prospective observational
Endpoint
Phylogenetically linked HIV transmission
Relevance
2
ResultZero linked transmissions in either PARTNER or PARTNER2.
Rodger AJ, et al. JAMA. 2016;316(2):171-181; Lancet. 2019;393(10189):2428-2438. 10.1016/S0140-6736(19)30418-0
Discussion & critique
Scientific basis of Undetectable = Untransmittable (U=U) — endorsed by WHO, CDC and >1,000 organisations.