Antibiotic duration
3 trials- 2025BALANCEBloodstream infectionIn 3,608 hospitalised adults with bloodstream infection (≈55 % ICU), 7 days of adequate antibiotic therapy was non-inferior to 14 days for 90-day mortality.
- 2019Yahav 2019Gram-negative bacteraemiaIn 604 patients with uncomplicated Gram-negative bacteraemia, 7 days of antibiotic therapy was non-inferior to 14 days for a composite of clinical failure, relapse and death at 90 days.
- 2015STOP-ITIntra-abdominal infectionIn 518 patients with complicated intra-abdominal infection after adequate source control, a fixed 4-day antibiotic course was equivalent to therapy until 2 days after resolution of physiological signs (~8 days) for surgical-site infection, recurrent IAI or death.