2024REVISEStress-ulcer prophylaxisIn 4,821 invasively ventilated ICU patients, pantoprazole reduced clinically important upper GI bleeding versus placebo, without an infectious harm signal.
2020PEPTICStress-ulcer prophylaxisIn 26,982 ventilated ICU patients, PPI prophylaxis did not change 90-day in-hospital mortality versus H₂-receptor antagonists.
2018SUP-ICUStress-ulcer prophylaxisIn 3,298 ICU patients at risk of GI bleeding, pantoprazole 40 mg/day did not change 90-day mortality versus placebo, but reduced clinically important GI bleeding.
2015EUROTHERM3235Temperature in TBIIn 387 patients with TBI and refractory raised intracranial pressure, therapeutic hypothermia 32–35 °C worsened 6-month functional outcome compared with standard care.
2011PROTECTVTE prophylaxisIn 3,764 medical-surgical ICU patients, dalteparin reduced pulmonary embolism compared with unfractionated heparin, without changing proximal DVT.