2023PATCH-TraumaIn 1310 adults with major trauma at coagulopathy risk, prehospital tranexamic acid did not improve 6-month survival with favourable function versus placebo.
2023UK-REBOAIn 90 trauma patients with exsanguinating torso haemorrhage, emergency-department REBOA plus standard care increased 90-day all-cause mortality compared with standard care alone.
2020Prehospital TXA for TBI TrialIn 966 patients with moderate or severe traumatic brain injury, out-of-hospital tranexamic acid did not improve 6-month neurologic outcome compared with placebo.
2019CRASH-3Tranexamic acidIn 12,737 patients with traumatic brain injury, tranexamic acid did not reduce head-injury death overall versus placebo, with benefit in mild–moderate TBI.
2018PAMPerPrehospital plasmaIn 501 trauma patients at risk of haemorrhagic shock during HEMS transport, 2 units of prehospital thawed plasma reduced 30-day mortality versus standard care.
2015PROPPRTrauma resuscitationIn 680 patients with severe trauma haemorrhage, a 1:1:1 plasma:platelet:RBC ratio did not change 24-hour or 30-day mortality versus 1:1:2, but reduced death from exsanguination at 24 hours.
2010CRASH-2Tranexamic acidIn 20,211 trauma patients with significant haemorrhage, tranexamic acid within 3 hours reduced all-cause death versus placebo.