HYPERION
Therapeutic Hypothermia after Cardiac Arrest in Non-Shockable Rhythm
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 581 patients resuscitated from cardiac arrest with a non-shockable rhythm, targeted hypothermia at 33 °C improved favourable neurological outcome compared with targeted normothermia.
N
581
Schéma
Open-label, blinded-endpoint RCT
Critère
Favourable neurological outcome at 90 days
Pertinence
3
Résultat10.2 % vs 5.7 %; statistically fragile.
Lascarrou JB, et al. N Engl J Med. 2019;381(24):2327-2337. 10.1056/NEJMoa1906661
Discussion et critique
The lone positive temperature trial — but in non-shockable rhythms only, and the result is statistically fragile. TTM2 found no overall benefit.