ALPS
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 3,026 adults with OHCA and shock-refractory VF/pVT, amiodarone or lidocaine did not improve survival to hospital discharge versus placebo.
N
3026
Disegno
Double-blind RCT, North America
Esito
Survival to hospital discharge
Rilevanza
3
Risultato24.4% (amiodarone) vs 23.7% (lidocaine) vs 21.0% (placebo); benefit in witnessed bystander-arrest subgroup.
Kudenchuk PJ, et al. N Engl J Med. 2016;374(18):1711-1722. 10.1056/NEJMoa1514204
Discussione e critica
Antiarrhythmics remain a weak recommendation; bystander CPR and early defibrillation are the real life-savers.