2014Morrison ACTIONAntipsychotic refusersIn 74 patients with schizophrenia who declined antipsychotics, CBT alone reduced PANSS total compared with treatment as usual.
2014Jauhar CBTpMeta-analysisAcross 52 RCTs of CBT for psychosis, CBTp produced small reductions in positive and overall symptoms relative to active and inactive controls.
2014Turner MAMeta-analysisAcross 48 head-to-head psychosocial trials, CBT and social skills training achieved better symptom-specific outcomes than befriending or supportive comparators.
2005CATIEPharmacology contextIn 1,493 patients with chronic schizophrenia, olanzapine, quetiapine, risperidone or ziprasidone achieved the same time to discontinuation as perphenazine, with most patients stopping treatment by 18 months.
2002SoCRATESFirst-episodeIn 315 first-episode psychosis patients, 5 weeks of CBT produced faster remission of auditory hallucinations and positive symptoms than supportive counselling or routine care.
2001Family Interv. MAFamily interventionAcross 25 RCTs of family interventions in schizophrenia, family-based programmes added to usual care reduced relapse compared with usual care alone.
2000Sensky CBTCBT for psychosisIn 90 patients with medication-resistant schizophrenia, 19 sessions of CBT produced more durable symptom improvement than a befriending control.
1997Kuipers CBTpCBT for psychosisIn 60 patients with medication-refractory psychotic symptoms, 9 months of individual CBT for psychosis produced higher 18-month improvement than standard care.