CATIE
Clinical Antipsychotic Trials of Intervention Effectiveness
Patient / Population Intervention / Exposure Comparison Outcome
In 1,493 patients with chronic schizophrenia, olanzapine, quetiapine, risperidone or ziprasidone achieved the same time to discontinuation as perphenazine, with most patients stopping treatment by 18 months.
N
1,493
Design
Multi-phase pragmatic RCT, USA
Endpoint
Time to all-cause discontinuation
Relevance
1
Result~74% discontinued within 18 months across arms; olanzapine had the longest time-to-discontinuation but most weight gain.
Lieberman JA, et al. N Engl J Med. 2005;353(12):1209-1223. 10.1056/NEJMoa051688
Discussion & critique
Backdrop for why psychosocial augmentation matters: even with modern antipsychotics, real-world adherence is poor.