2022BOX (BP)Haemodynamic targetsIn 789 comatose survivors of OHCA, a higher MAP target (77 mm Hg) did not change the composite of death or severe disability versus a lower target (63 mm Hg).
2022BOX (O₂)Oxygen targetsIn 789 comatose survivors of OHCA, restrictive oxygenation (PaO₂ 68–75 mm Hg) did not change the composite of death or severe disability compared with liberal (98–105 mm Hg).
2022HACA-IHCAIn 249 comatose adults resuscitated after in-hospital cardiac arrest, hypothermia at 32-34°C did not reduce 180-day mortality compared with normothermia.
2021TTM2Temperature managementIn 1,861 unconscious adults after OHCA, hypothermia at 33 °C did not reduce all-cause mortality at 6 months compared with targeted normothermia (≤ 37.5 °C).
2021TOMAHAWKImmediate angiographyIn 554 OHCA patients without ST-elevation, immediate angiography did not improve 30-day all-cause mortality versus delayed/selective strategy.
2019HYPERIONTemperature managementIn 581 patients resuscitated from cardiac arrest with a non-shockable rhythm, targeted hypothermia at 33 °C improved favourable neurological outcome compared with targeted normothermia.
2019COACTImmediate angiographyIn 552 OHCA survivors with a shockable rhythm and no STEMI, immediate coronary angiography did not improve 90-day survival versus delayed angiography.
2016RINSEIn 1198 adults with out-of-hospital cardiac arrest, intra-arrest cold saline infusion did not improve survival to hospital discharge compared with standard prehospital care.
2015THAPCA-OHIn 295 comatose children after out-of-hospital cardiac arrest, hypothermia did not improve 1-year survival with good neurobehavioural function vs normothermia.
2013TTMTemperature managementIn 939 unconscious survivors of out-of-hospital cardiac arrest, targeted temperature of 33 °C did not improve survival or neurological outcome compared with 36 °C.
2010RICHIn 234 adults resuscitated from VF cardiac arrest, prehospital paramedic cooling did not improve discharge functional outcome versus in-hospital cooling.