WOEST

What is the Optimal antiplatelet and anticoagulant therapy in patients with OAC and coronary StenTing

Patient / Population Intervention / Exposition Comparaison Critère de jugement

In 573 patients on oral anticoagulation undergoing PCI, clopidogrel without aspirin reduced bleeding compared with triple therapy.

573

Schéma

Open-label RCT

Critère

Any bleeding at 1 year

Pertinence

Résultat19.4 % vs 44.4 % (HR 0.36); no increase in thrombotic events.

Dewilde WJM, et al. Lancet. 2013;381(9872):1107-1115. 10.1016/S0140-6736(12)62177-1

Discussion et critique

First trial of 'less is more' antithrombotics — small, open-label, not powered for ischaemic events. Set a direction later confirmed decisively by AUGUSTUS.