STARRT-AKI

Standard versus Accelerated Initiation of RRT in Acute Kidney Injury

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In 3,019 critically ill patients with acute kidney injury, accelerated renal-replacement therapy did not reduce mortality and increased dialysis dependence compared with a standard strategy.

N
3019
Disegno
International RCT
Esito
90-day all-cause mortality
Rilevanza
1
Risultato43.9% vs 43.7%; RR 1.00 (95% CI 0.93–1.09); 90-day dialysis dependence 10.4% vs 6.0%.
STARRT-AKI Investigators. N Engl J Med. 2020;383(3):240-251. 10.1056/NEJMoa2000741
Discussione e critica

The definitive trial against accelerated RRT initiation; supports complication-guided timing.