STARRT-AKI
Standard versus Accelerated Initiation of RRT in Acute Kidney Injury
Patient / Population Intervention / Exposure Comparison Outcome
In 3,019 critically ill patients with acute kidney injury, accelerated renal-replacement therapy did not reduce mortality and increased dialysis dependence compared with a standard strategy.
N
3,019
Design
International RCT
Endpoint
90-day all-cause mortality
Relevance
1
Result43.9% vs 43.7%; RR 1.00 (95% CI 0.93–1.09); 90-day dialysis dependence 10.4% vs 6.0%.
STARRT-AKI Investigators. N Engl J Med. 2020;383(3):240-251. 10.1056/NEJMoa2000741
Discussion & critique
The definitive trial against accelerated RRT initiation; supports complication-guided timing.