SPRINT

Systolic Blood Pressure Intervention Trial

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In 9,361 high-risk non-diabetic hypertensive adults, intensive BP control to SBP < 120 mm Hg reduced CV events and all-cause mortality compared with standard control to SBP < 140 mm Hg.

9361

Disegno

Open-label RCT, terminated early at median 3.3 yr

Esito

MI, ACS, stroke, HF or CV death

Rilevanza

Risultato1.65 vs 2.19 % per year (HR 0.75). Mortality HR 0.73. More AKI/syncope with intensive.

SPRINT Research Group. N Engl J Med. 2015;373(22):2103-2116. 10.1056/NEJMoa1511939

Discussione e critica

Automated office BP — readings ~ 5-10 mm Hg lower than typical clinic BP, so targets don't translate 1:1. Excluded diabetes and stroke history.