SPRINT-CKD
Systolic Blood Pressure Intervention Trial — chronic kidney disease subgroup
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 2,646 participants with chronic kidney disease, an intensive systolic-BP target below 120 mmHg reduced all-cause mortality compared with a target below 140 mmHg.
N
2.646
Design
Prespecified subgroup of an open-label RCT
Endpunkt
Cardiovascular composite; all-cause mortality
Relevanz
2
ErgebnisAll-cause mortality HR 0.72 (0.53–0.99); CV composite HR 0.81 (0.63–1.05) and kidney outcome HR 0.90 (0.44–1.83) (both NS).
Cheung AK, et al. J Am Soc Nephrol. 2017;28(9):2812-2823. 10.1681/ASN.2017020148
Diskussion & Kritik
Underpins the KDIGO 2021 target of SBP <120 mmHg by standardised measurement; people with diabetes, polycystic kidneys and proteinuria >1 g/day were excluded.