REDUCE-IT
Reduction of Cardiovascular Events with Icosapent Ethyl
Patient / Population Intervention / Exposure Comparison Outcome
In 8,179 statin-treated patients with high triglycerides, icosapent ethyl reduced major adverse cardiovascular events compared with placebo.
N
8,179
Design
Double-blind RCT
Endpoint
CV death, MI, stroke, revascularisation or unstable angina
Relevance
2
Result17.2 % vs 22.0 % (HR 0.75).
Bhatt DL, et al. N Engl J Med. 2019;380(1):11-22. 10.1056/NEJMoa1812792
Discussion & critique
The mineral-oil placebo raised LDL and CRP, so the true effect is probably smaller than the 25 % reduction. STRENGTH, with a different omega-3, was negative.