PARAMEDIC2
Adrenaline versus Placebo in Out-of-Hospital Cardiac Arrest
Patient / Population Intervention / Exposure Comparison Outcome
In 8,014 adults with OHCA, 1 mg intravenous adrenaline increased 30-day survival versus placebo, without improving favourable neurologic survival.
N
8,014
Design
Double-blind RCT, UK
Endpoint
30-day survival
Relevance
1
Result3.2% vs 2.4% (OR 1.39; p=0.02). Favourable neurologic survival 2.2% vs 1.9% (NS).
Perkins GD, et al. N Engl J Med. 2018;379(8):711-721. 10.1056/NEJMoa1806842
Discussion & critique
Modest survival gain at the cost of more severe-disability survivors — central debate in resuscitation ethics.