PAMPer
Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 501 trauma patients at risk of haemorrhagic shock during HEMS transport, 2 units of prehospital thawed plasma reduced 30-day mortality versus standard care.
N
501
Disegno
Cluster-randomised RCT, US air ambulance
Esito
30-day mortality
Rilevanza
3
Risultato23.2% vs 33.0% (Δ −9.8; 95% CI −18.6 to −1.0; p=0.03; adj. HR 0.61).
Sperry JL, et al. N Engl J Med. 2018;379(4):315-326. 10.1056/NEJMoa1802345
Discussione e critica
Supports prehospital plasma in helicopter EMS — implementation hinges on logistics.