OPAL-HK
Patiromer in Patients with CKD and Hyperkalaemia on RAAS Inhibitors
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 243 patients with CKD and hyperkalaemia on RAAS inhibitors, patiromer lowered serum potassium and recurrent hyperkalaemia compared with placebo withdrawal.
N
243
Disegno
Single-blind, two-phase trial with randomised withdrawal
Esito
Change in serum potassium; recurrent hyperkalaemia
Rilevanza
3
RisultatoPotassium −1.01 mmol/L (p<0.001); recurrence 15% vs 60% on withdrawal (p<0.001).
Weir MR, et al. N Engl J Med. 2015;372(3):211-221. 10.1056/NEJMoa1410853
Discussione e critica
Enabled continuation of RAAS inhibitors despite hyperkalaemia; led to approval of patiromer.