NUTRIREA-2
Early Enteral versus Parenteral Nutrition in Shock
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 2,410 ventilated patients on vasopressors, early enteral nutrition did not change 28-day mortality versus early parenteral nutrition, but caused more bowel ischaemia.
N
2410
Disegno
Multicentre RCT, France
Esito
28-day all-cause mortality
Rilevanza
2
Risultato37% vs 35% (absolute difference 2.0%, 95% CI -1.9 to 5.8; p=0.33). Bowel ischaemia 2% vs <1% (HR 3.84).
Reignier J, et al. Lancet. 2018;391(10116):133-143. 10.1016/S0140-6736(17)32146-3
Discussione e critica
Hold EN in patients on rising vasopressors — bowel ischaemia is a real risk.