CALORIES
Early Enteral or Parenteral Nutrition in Critical Illness
Patient / Population Intervention / Exposure Comparison Outcome
In 2,400 critically ill adults, early parenteral nutrition did not change 30-day mortality compared with early enteral nutrition.
N
2,400
Design
Multicentre RCT, UK
Endpoint
30-day all-cause mortality
Relevance
3
Result33.1% (parenteral) vs 34.2% (enteral); RR 0.97 (95% CI 0.86–1.08), p=0.57.
Harvey SE, et al. N Engl J Med. 2014;371(18):1673-1684. 10.1056/NEJMoa1409860
Discussion & critique
Route matters less than once thought, provided initial resuscitation is complete.