MADIT-II
Multicenter Automatic Defibrillator Implantation Trial II
Patient / Population Intervention / Exposure Comparison Outcome
In 1,232 patients with prior MI and an ejection fraction ≤ 30 %, a prophylactic implantable defibrillator reduced all-cause mortality compared with conventional therapy.
N
1,232
Design
RCT
Endpoint
All-cause mortality
Relevance
1
Result14.2 % vs 19.8 % (HR 0.69).
Moss AJ, et al. N Engl J Med. 2002;346(12):877-883. 10.1056/NEJMoa013474
Discussion & critique
Shifted ICD selection to ejection fraction alone, abandoning electrophysiology testing. Defined the post-MI primary-prevention population.