DANISH
Danish Study to Assess the Efficacy of ICDs in Non-Ischaemic Systolic Heart Failure
Patient / Population Intervention / Exposure Comparison Outcome
In 1,116 patients with non-ischaemic heart failure (EF ≤ 35 %), a prophylactic defibrillator did not reduce all-cause mortality compared with usual care.
N
1,116patients
Design
RCT, median 5.6 yr
Endpoint
All-cause mortality
Relevance
2Important — one of several pillars.
Result21.6 % vs 23.4 % (HR 0.87, ns); sudden death halved (HR 0.50).
Køber L, et al. N Engl J Med. 2016;375(13):1221-1230. 10.1056/NEJMoa1608029
Cited in guidelines
Discussion & critique
Reopened the non-ischaemic ICD question in the modern GDMT era. Younger patients clearly benefit; high background CRT use dilutes the overall result.