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Semaglutide and Kidney Outcomes in Type 2 Diabetes with Chronic Kidney Disease

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In 3,533 patients with type 2 diabetes and CKD, semaglutide reduced the composite of kidney failure, ≥50% eGFR decline or renal/CV death compared with placebo.

3533

Disegno

Double-blind RCT, stopped early

Esito

Kidney failure, ≥50% eGFR decline, or renal or CV death

Rilevanza

RisultatoHR 0.76 (95% CI 0.66–0.88; p=0.0003); all-cause mortality HR 0.80.

Perkovic V, et al. N Engl J Med. 2024;391(2):109-121. 10.1056/NEJMoa2403347

Discussione e critica

First GLP-1-agonist trial with a dedicated renal hard endpoint; the benefit was numerically attenuated in the ~16% on background SGLT2 inhibitors.