EPaNIC
Early versus Late Initiation of Parenteral Nutrition
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 4,640 ICU patients with insufficient enteral intake, late parenteral nutrition (after day 7) accelerated live ICU discharge compared with early parenteral nutrition.
N
4.640
Design
Multicentre RCT, Belgium
Endpunkt
Time to live discharge from the ICU
Relevanz
2
ErgebnisHR 1.06 for earlier discharge (p=0.04); fewer infections; less RRT.
Casaer MP, et al. N Engl J Med. 2011;365(6):506-517. 10.1056/NEJMoa1102662
Diskussion & Kritik
Avoid early supplemental PN; let permissive underfeeding ride for the first week.