EARLY-AF
Early Aggressive Invasive Intervention for Atrial Fibrillation
Patient / Population Intervention / Exposition Comparaison Critère de jugement
In 303 patients with paroxysmal AF, first-line cryoballoon ablation reduced atrial arrhythmia recurrence compared with antiarrhythmic drugs.
N
303
Schéma
Open-label RCT with continuous monitoring
Critère
Recurrent atrial tachyarrhythmia at 1 year
Pertinence
2
Résultat42.9 % vs 67.8 % (HR 0.48).
Andrade JG, et al. N Engl J Med. 2021;384(4):305-315. 10.1056/NEJMoa2029980
Discussion et critique
With STOP-AF First and Cryo-FIRST, established ablation as a first-line option. PROGRESSIVE-AF later showed less progression to persistent AF.