EARLY-AF
Early Aggressive Invasive Intervention for Atrial Fibrillation
Paciente / Población Intervención / Exposición Comparación Desenlace
In 303 patients with paroxysmal AF, first-line cryoballoon ablation reduced atrial arrhythmia recurrence compared with antiarrhythmic drugs.
N
303
Diseño
Open-label RCT with continuous monitoring
Desenlace
Recurrent atrial tachyarrhythmia at 1 year
Relevancia
2
Resultado42.9 % vs 67.8 % (HR 0.48).
Andrade JG, et al. N Engl J Med. 2021;384(4):305-315. 10.1056/NEJMoa2029980
Discusión y crítica
With STOP-AF First and Cryo-FIRST, established ablation as a first-line option. PROGRESSIVE-AF later showed less progression to persistent AF.