DANISH

Danish Study to Assess the Efficacy of ICDs in Non-Ischaemic Systolic Heart Failure

Paziente / Popolazione Intervento / Esposizione Confronto Esito

In 1,116 patients with non-ischaemic heart failure (EF ≤ 35 %), a prophylactic defibrillator did not reduce all-cause mortality compared with usual care.

1116

Disegno

RCT, median 5.6 yr

Esito

All-cause mortality

Rilevanza

Risultato21.6 % vs 23.4 % (HR 0.87, ns); sudden death halved (HR 0.50).

Køber L, et al. N Engl J Med. 2016;375(13):1221-1230. 10.1056/NEJMoa1608029

Discussione e critica

Reopened the non-ischaemic ICD question in the modern GDMT era. Younger patients clearly benefit; high background CRT use dilutes the overall result.