CURE
Clopidogrel in Unstable Angina to Prevent Recurrent Events
Paziente / Popolazione Intervento / Esposizione Confronto Esito
In 12,562 patients with NSTE-ACS, clopidogrel plus aspirin reduced the composite of CV death, MI or stroke versus aspirin alone.
N
12.562
Disegno
Double-blind RCT, 3–12 mo follow-up
Esito
CV death, non-fatal MI or stroke
Rilevanza
1
Risultato9.3 % vs 11.4 % (RR 0.80). Major bleeding 3.7 % vs 2.7 %.
Yusuf S, et al. N Engl J Med. 2001;345(7):494-502. 10.1056/NEJMoa010746
Discussione e critica
Established DAPT as standard for NSTE-ACS. Bleeding signal is real and shaped later trials (CURRENT-OASIS 7, PLATO, TRITON).