CRYSTAL AF
Cryptogenic Stroke and Underlying Atrial Fibrillation
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 441 patients with recent cryptogenic stroke, an insertable cardiac monitor detected atrial fibrillation more often than conventional follow-up.
N
441
Design
Multicentre open-label RCT
Endpunkt
Time to first detection of AF (episode >30 s) at 6 months
Relevanz
3
ErgebnisAF detected in 8.9% vs 1.4% at 6 months (HR 6.4, 95% CI 1.9-21.7; P<0.001); the detection gap widened over 36 months.
Sanna T, et al. N Engl J Med. 2014;370(26):2478-2486. 10.1056/NEJMoa1313600
Diskussion & Kritik
AF detection is a surrogate; the trial was not powered for recurrent stroke reduction and the optimal AF-duration threshold remains debated. Established prolonged monitoring with insertable cardiac monitors after cryptogenic stroke.