COMBINE

Combined Pharmacotherapies and Behavioural Interventions

Patient / Population Intervention / Exposition Comparaison Critère de jugement

In 1,383 adults with alcohol dependence, medical management plus naltrexone or combined behavioural intervention reduced heavy-drinking days relative to placebo or acamprosate, with no additive effect.

1 383

Schéma

9-arm RCT, USA

Critère

Percent days abstinent and time to heavy-drinking relapse

Pertinence

RésultatNaltrexone (HR 0.72) and CBI each effective with medical management; acamprosate no effect; no additive benefit.

Anton RF, et al. JAMA. 2006;295(17):2003-2017. 10.1001/jama.295.17.2003

Discussion et critique

Established a flexible pharma + behavioural toolkit; the long-debated acamprosate signal failed in this US sample.