COLO-DETECT
Polyp detection with colonoscopy assisted by the GI Genius artificial intelligence endoscopy module compared with standard colonoscopy in routine colonoscopy practice
Patient / Population Intervention / Exposition Vergleich Endpunkt
In 2,032 adults undergoing screening or symptomatic colonoscopy at 12 NHS hospitals in England, computer-aided detection with the GI Genius module increased mean adenomas per procedure compared with standard colonoscopy.
N
2.032
Design
Multicentre open-label pragmatic RCT, UK
Endpunkt
Mean adenomas per procedure
Relevanz
2
ErgebnisAdenomas per procedure 1.56 vs 1.21 (adjusted mean difference 0.36, 95% CI 0.14–0.57; adjusted IRR 1.30, 95% CI 1.15–1.47; P<0.0001). ADR 56.6% vs 48.4% (difference 8.3%, 95% CI 3.9–12.7; aOR 1.47, 95% CI 1.21–1.78). Adverse events 25 vs 19, none attributed to the device.
Seager A, et al. Lancet Gastroenterol Hepatol. 2024;9(10):911-923. 10.1016/S2468-1253(24)00161-4
Diskussion & Kritik
The largest pragmatic CADe trial in routine practice and the UK evidence base for GI Genius, extending the Repici result to unselected NHS lists with screening and symptomatic indications. Open-label with unmasked colonoscopists, a polyp-count surrogate rather than cancer outcomes, imputation for missing outcome data, and Medtronic funding.